Mestinon doesn't work for me. We tried several different doses, and I couldn't even get to 1 full pill a day without my muscles in my legs and face starting to tingle and have spasms (so bad you can see them, even through jeans ).

I have the MuSK myasthenia, and when I was telling my neuromuscular dr about my reactions to the Mestinon he just gave a look like, "I figured that's what would happen and it wouldn't work" because of that. We've tried adjusting dosages, and I did it for about 2 weeks before I said I couldn't take it anymore.