I use them for what I call my flare-ups. That is when the burning feels as though someone has placed a hot iron on my palms and the soles of my feet. I pay $40 for 180 patches through my insurance. I usually cut each patch into four pieces. I place 1 piece on each foot, directly below the toes. I do the same with my hands, directly below the fingers. Then I cover my hands with gloves that have the fingers removed, and cover my feet, if able, with a light pair of socks. If pain is really an issue, I only cut the patch in half to cover more surface area. I have worn the patches on my feet inside my work shoes and did not have trouble with them bunching up. It is whatever works on any given day. You just pull out your "bag of tricks" and keep digging till you find one that works. Good night, all!