Hi Johnt,
for th first link, try searching for
"The blood-brain barrier (BBB) is a layer of cells, including endiothelial cells,which line the "
this gives the correct link,
http://www.qmul.ac.uk/media/news/ite...ampaign=Slide2
If the BBB permeability is increased, there is every possibility that dopamine could cross it. We have dopamine in our blood for anotherr purpose, as a hormone to regulate our heart rate. Dopamine is actually a smaller molecule than levodopa, yet can't cross while levodopa can. The reason is the fat solubility of levodopa is higher.
Dianna,
If you blocked the BBB, your Sinemet would not get through and no dopamine would reach it's target. Blocking it would not let anything through, good or bad. I think that the 80% of cells may just be inactivated, not necessasrily dead. I think here is a controversy over this. We have to hoper they are just inactivated.
Ron
Quote:
Originally Posted by johnt
Thanks Ron.
I can't get the first link to work. It goes off into google. If you could just paste the search term, we could add the google bit.
The second link works fine and takes us to your well argued comment.
If the BBB is compromised, perhaps, dopamine can cross it. Is there good evidence for this in PwP?
John
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