I also experience a considerable amount of pain and stiffness, most noticeably after recently discontinuing the prednisone (under my neurologist's supervision). When I was on prednisone I had few episodes of weakness and no stiffness/aching. Now it's constant. I don't notice the symptoms to be more prominent on one side of my body, though I have noticed in the past that it affected my right side more.

I have increased the frequency that I take Mestinon and this has helped with the weakness. I just take Tylenol for the stiffness/achiness and that helps to relieve it a bit. I'm not able to take ibuprofen due to other medication that I'm taking.

I know that my neurologist will want me to start back on prednisone, though I hesitate to do that b/c of side effects I've experienced being on the pred before.

It's a difficult balance. I am now more aware of my triggers and work to manage all of that. Lack of sleep is one of my biggest triggers.

I am seronegative, tensilon positive.
Cate