Hi again, RSDMom and Christine,
Here are some of the links I've gathered - but I can't get into many of the full texts, maybe someone here can help you out with that.
The first place to look is Holland, because the Netherlands are doing more research into CRPS/RSD than anyone else.
http://www.crps.nl/care_providers_+_....htm#_Genetics
"The aetiology of CRPS-1 is unknown, but there are indications that genetic factors are involved in this disease. Until now, the nature and significance of these genetic mechanisms have not been studied thoroughly. Two pilot studies at the department of Neurology of the Leiden University Medical Center provided evidence of familial clustering of CRPS-1 beyond what might have been expected based on current knowledge of prevalence rates. Although this finding may be partly explained by shared environmental factors, genetic influences are probably involved. The aim of this research line is to evaluate the extent to which genetic factors are involved in the initiation and progression of CRPS-1 and to study the nature of this involvement. Data is collected in three different ways, all of which involve the collection of DNA from both affected and unaffected family members. In the first approach families with at least two CRPS patients are collected. Linkage analysis in extended families and/or affected sib pair analysis in a large number of sibs will be used to determine the approximate chromosomal location of potentially involved disease genes. For the affected sib pair analysis we aim to include at least 160 affected sib pairs. In the second approach our objective is to enrol at least 325 family trios (patient and both parents) or nuclear families (patient and first-degree relatives) to assess association, using the DNA of parents, sibs or children as control samples. (Blood samples collected by the first approach will also be used in the second approach.) In the third approach the relative importance of environmental and genetic factors in the onset and progression of CRPS will be studied, using the data on the prevalence of CRPS and other trauma-induced syndromes (repetitive strain injury, fibromyalgia) from the Netherlands Twin Register.
With this approach we hope to determine the relative importance of genetic factors in CRPS-1 and to identify the loci involved in this disease. Knowledge of the responsible genes may enhance our understanding of the disease pathway, indicate directions for future research, and may ultimately help to identify potentially efficacious pharmatherapeutic interventions or yield targets for drug development.
For more information about this research line, please contact
genetics@crps.nl"
Here are a few other links:
http://www.onderzoekinformatie.nl/en...ek/OND1317555/
Genetics of Complex Regional Pain Syndrome type 1
Period 03/2005 - 02/2013
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed
Pain. 2003 May;103(1-2):93-7.
"Susceptibility loci for complex regional pain syndrome."
van de Beek WJ, Roep BO, van der Slik AR, Giphart MJ, van Hilten BJ.
Department of Neurology, Leiden University Medical Center, P.O. Box 9600, 2300 RC, Leiden, The Netherlands.
http://www.ncbi.nlm.nih.gov/entrez/q...&dopt=Abstract
Ann Neurol. 2000 Jul;48(1):113-6.
"Multifocal or generalized tonic dystonia of complex regional pain syndrome: a distinct clinical entity associated with HLA-DR13."
van Hilten JJ, van de Beek WJ, Roep BO.
"An association between HLA-DR13 and patients with complex regional pain syndrome (CRPS) who progressed towards multifocal or generalized tonic dystonia was recently reported. We now report on a new locus, centromeric in HLA-class I, which was significantly associated with a spontaneous development of CRPS, suggesting an interaction between trauma severity and genetic factors conferring CRPS susceptibility. Additionally, an association with the D6S1014 locus was found, supporting the previous finding of an association with HLA-DR13."
Good luck, if you find anything, please keep us informed,
all the best!