Now you have me thinking. I suspect that there is a lot of stuff that is not known yet. People like those of us that are seronegative might actually have something totally different; it may or may not be an autoimmune disorder.

There are two different conditions in horses that cause severe muscle weakness that hit in "spells" sort of like what we tend to do. One is due to an inability to use carbohydrates correctly. The second is a genetic disorder that screws up potassium use. The potassium disorder can all be traced back to one horse, a stallion named "Impressive".

The closest thing to the "Impressive" problem that I could find in humans is hyperkalemic periodic paralysis. Interestingly enough, it responds to hydrochlorothiazide. Hmmmmmm.

http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001359/


http://www.vet.k-state.edu/depts/vhc...e/tying.up.htm

http://www.foundationhorses.com/impressive_syndrom.aspx

http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001359/