Thinking more about hypokalemic periodic paralysis. Maybe it's a better fit than I'd thought. Today I ate breakfast at 8:00 and had to rush out at noon for an appointment, and didn't eat lunch. At about 1:00, I got weak. This is unusual for me. Usually I get weak at around 5:00...which is five hours after lunch. So I'm wondering whether it's the five-hour fast that is triggering the spells. What's confusing is that sometimes I get weak before eating, and sometimes after. I had concluded that eating therefore isn't the cause. But HypoKPP can be triggered by getting to hungry, or eating a carby/salty meal--or by eating after being too hungry.

Another trigger is resting, especially after exercise. Sitting in a movie theater or in church almost always triggers a spell of weakness. I walk in just fine, but can hardly walk out. This is not typical of MG. What confuses me is that I spend a lot of time on the computer at home (I do editing), and I haven't noticed that that makes me weak. Can anyone make sense of that?

HypoKPP is a dominant genetic disorder (though about a third of diagnosed patients are new mutations). But the symptoms can be so mild that it's never diagnosed in one family member, but severe in another. So my healthy parents and seven healthy siblings don't necessarily rule it out.

If I have HypoKPP, then HCTZ is the wrong drug for me. I wish I could remember when I started taking it for migraines. It could be that my symptoms appeared at that time.

I have a question about fatiguability, but I'll ask it in its own thread.

Thank you, thank you, thank you to all of you who are helping me with this.

Abby