--the values are certainly below the means, but the fluctuations are so wide that when the McArthur protocols were established I do think they erred on the side of underdiagnosing, it choosing 5th and 95th percentile cutoffs as incontrovertible evidence of small fiber damage.


I haven't seen much distinction in the studies as regards males/females--the original enumeration of 'normal' subjects included both in roughly equal numbers.

The search for a cause of this may be long and expensive--and a lot of these small fiber syndromes remain stubbornly idiopathic. Often, toxic, autoimmune, or glucose dysregulation mechanisms are considered possible etiologies, but are hard to prove.

What other kinds of testing have you had? And have you seen the Liza Jane spreadsheets (which were developed to be about as comprehensive a lists of tests for neurological symptoms that the good minds here could think of)?--

www.lizajane.org