Mike,

Some people find opioids help. So the idea these do NOT work or make pain worse is just not the case IMO and you even proved it yourself.

I think it all depends on what is causing the PN (whether known or not). I know for me it (percocet in small doses) does not completely take the pain away, but it takes the edge off and that makes life easier. I've tried lyrica, neurontin, cymbalta, ...the list goes on. They didn't help or side effects were too great.

Keep in mind that some have improvement just from increased B12. It really is an individual condition and each person needs to find what works for them.