I'm still trying to figure my dosage out. At times I take too much and other times not enough. Lately some of my muscles were weaker so I took more, but then became even weaker so I found that if I skipped my morning dose of 60 mg then I felt better. I usually take four pills a day after that every four hours. Mestinon seems to be a bit tricky because it's hard to tell if the weakness is from too much or too little.