LEMON, just trying to be helpful.

for a patient just starting on sinemet, the normal dosage is 300-400mg/day. i'm not saying take sinemet, just trying to impress upon you how little dopamine the brain needs daily.

that's 300-400mg of levodopa which gets converted to dopamine in the brain. of that amount, it is estimated less than 10% gets into the brain, the other 90% gets converted to dopamine outside the brain so can't get into the brain. so 30-40mg getting into the brain is all that is needed to treat an early pd'er. obviously there are checks and balances on not letting too much amino acids getting into cells, too much would kill them. plus in early pd dopamine is stored in the cells, you have a buffer.

i just don't understand how anyone eating a balanced diet can have a dopamine precursor deficiency.