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In Remembrance
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Join Date: Aug 2006
Posts: 3,772
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In Remembrance
Join Date: Aug 2006
Posts: 3,772
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'lo Ron
I have been meaning to write and may do so yet. I hope you and Margaret have been keeping warm and dry. Beastly weather you've been having!
But for now, I went to PubMed and did a litttle noseing around and found a few things that you may not have tried yet.
1) Modulation of levodopa-induced motor response complications by NMDA antagonists in Parkinson's disease.
Blanchet PJ, Papa SM, Metman LV, Mouradian MM, Chase TN.
Neurosci Biobehav Rev. 1997 Jul;21(4):447-53. Review.
PMID: 9195602
You may recall that RLSmi takes dextromethorphan, a common cough syrup. It is an NMDA antagonist. Being that it seems both safe and cheap, it might be worth a try.
2) Oral creatine supplementation attenuates L-DOPA-induced dyskinesia in 6-hydroxydopamine-lesioned rats.
Valastro B, Dekundy A, Danysz W, Quack G.
Behav Brain Res. 2009 Jan 30;197(1):90-6. doi: 10.1016/j.bbr.2008.08.004. Epub 2008 Aug 12.
PMID: 18762218
Again, cheap and safe.
3) Modulation of dopamine receptor sensitivity by estrogen.
Gordon JH, Borison RL, Diamond BI.
Biol Psychiatry. 1980 Jun;15(3):389-96.
PMID: 7189674
If RLSmi is reading this, I'd like to know if, assuming you still take the DXM, you have much trouble with dyskinesias?
Good luck.
-Rick
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Born in 1953, 1st symptoms and misdiagnosed as essential tremor in 1992. Dx with PD in 2000.
Currently (2011) taking 200/50 Sinemet CR 8 times a day + 10/100 Sinemet 3 times a day. Functional 90% of waking day but fragile. Failure at exercise but still trying. Constantly experimenting. Beta blocker and ACE inhibitor at present. Currently (01/2013) taking ldopa/carbadopa 200/50 CR six times a day + 10/100 form 3 times daily. Functional 90% of day. Update 04/2013: L/C 200/50 8x; Beta Blocker; ACE Inhib; Ginger; Turmeric; Creatine; Magnesium; Potassium. Doing well.
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