Originally Posted by reverett123

I have been meaning to write and may do so yet. I hope you and Margaret have been keeping warm and dry. Beastly weather you've been having!

But for now, I went to PubMed and did a litttle noseing around and found a few things that you may not have tried yet.

1) Modulation of levodopa-induced motor response complications by NMDA antagonists in Parkinson's disease.
Blanchet PJ, Papa SM, Metman LV, Mouradian MM, Chase TN.
Neurosci Biobehav Rev. 1997 Jul;21(4):447-53. Review.
PMID: 9195602

You may recall that RLSmi takes dextromethorphan, a common cough syrup. It is an NMDA antagonist. Being that it seems both safe and cheap, it might be worth a try.

2) Oral creatine supplementation attenuates L-DOPA-induced dyskinesia in 6-hydroxydopamine-lesioned rats.
Valastro B, Dekundy A, Danysz W, Quack G.
Behav Brain Res. 2009 Jan 30;197(1):90-6. doi: 10.1016/j.bbr.2008.08.004. Epub 2008 Aug 12.
PMID: 18762218

Again, cheap and safe.

3) Modulation of dopamine receptor sensitivity by estrogen.
Gordon JH, Borison RL, Diamond BI.
Biol Psychiatry. 1980 Jun;15(3):389-96.
PMID: 7189674

If RLSmi is reading this, I'd like to know if, assuming you still take the DXM, you have much trouble with dyskinesias?

Good luck.
-Rick