Hello mrsD! Thank you for your response. My doctor does know that I am taking the licorice root, but not the Rhodiola or Pregnenolone. Through what I have researched there isn't many interactions with Rhodiola. Pregnenolone is what I am worried about, chiefly. I haven't discussed usage with my doctor because it is so difficult to get ahold of him! So please, share your knowledge if you have any on these supplements and if they are safe. I will check the website, but mainly I don't use it as I worry some less commonly used drug combinations will not be logged.