I dumped approximately half of the powder out of 6 of the 25mg capsules, and have taken the 5th capsule last nite. One more nite & I am moving up to the (full) 25mg caps. The only thing I've felt so far is a touch of anxiety, which may be related from withdrawal from the Gabapentin, as I'm down to 1/4 the daily dose that I was on before beginning my taper. I'm also am having trouble sleeping, now. Slept good on 2400mg of Gabapentin daily, but the brain fog wasn't really worth it & it wasn't doing much of anything for my pain, anymore. I built tolerance to it really fast. Too soon for any relief by Nortriptyline.