Even the GATA1 gene we all have as well (the bad gene that was stated in that article you posted to be responsible for brain loss in the prefrontal cortex)? I'm sorry if it seems I'm asking the same questions, it's just that I have things on my mind with this.

Now it stated in that article that a loss of brain mass in the prefrontal cortex occurs. But you said that there is evidence that just a loss of activity in that area occurs and not a loss of brain mass in that area (shrinkage). Therefore, due to this contradictory information, is it unknown if a loss of brain mass occurs in that area through depression?

Like here it says that this shrinkage is known to occur in depressed people (the 5th paragraph of this article):

http://www.dailymail.co.uk/health/ar...ink-brain.html

But as stated before, you said there is information that contradicts this. And again, leading back to the question of is it unknown whether this shrinkage actually occurs in depressed people. I do have chronic major depressive disorder, and is there information out there that even shows people who have major depression have a normal sized prefrontal cortex or even a bigger one? Again, just wanting to learn in asking these questions.