Here is how I understand the isradipine "story"

1)If it works at all -- it is a mild disease modifier -- not neuro protective -- absolutely not a cure.

2)Only PWP's that already have high blood pressure that is treated with medication should give any thought to switching to isradipine at an effective dosage to manage their blood pressure -- the PD benefit would just be a bonus. (according to my MDS)

3)The clinical trials to find a "safe dosage" for PWPs were designed to use isradipine even in PWPs with normal or low orthostatic blood pressure readings -- thus the very low 10mg / day finding.