My calves are aching, they are not tight. I have tried magnesium and tons of other nutritionals. John Seneff has written extensively on Nutrition for Neuropathy and I was on his program for years. Lots of magnesium, all forms of Bs, primrose oil, fish oil, too many to remember. Wish they helped but they don't, twitching and aching still there. Have had lots of nutritional testing, too, hair, blood, urine; no deficiencies.