Hi rsdno. I have RSD in my left leg. I used to be energetic, went to the gym, and danced. Since the RSD took over a broken tibia plateau with two surgeries, I have depression. I take Wellbutrin now after trying several antidepressants. I can't do the things I use to do. Even walking is difficult. I can only work part-time now, and I have gained 25 lbs in the last three years. So yes, I would say mental illness goes along with RSD.