No not in a general sense.

I think much of what is "anti-supplement" is propaganda from drug companies. They don't want you to feel better, they want you to buy their drugs instead.

Very high doses of some supplements can cause vitamin dependency. This was found with Vit C when people took it is massively high doses. When suddenly stopped those people developed signs of scurvy. But this is not a documented situation for most people.

The oral B12 is very absorbed in very small amounts. 1000mcg dose will provide only 13mcg to the blood stream. The injections are far more massive than oral.

Our foods are deteriorating quite a bit. Storage before sale...lowers the natural nutrients those whole foods contain.
Our soils are becoming depleted, as well.

People gobbling up acid blocking drugs OTC for long periods of time are resulting in low

B12
folate
calcium
zinc
iron
magnesium
and some of the trace minerals also (newest information).

When you take these drugs and lower stomach acid, protein is not digested properly and hence amino acids, are not absorbed as they should be. The bacteria in the bowel ferment them instead, and they get the benefits.

As the genome is explored, it is thought that genetic aberrations that people have, are causing nutrient errors. We already know that MTHFR mutation, prevents methylation of B12 and folic acid in the body. 10-30% of people have this DNA error. It is thought that other errors may exist, in the B complex family as well. We know that some Asians, for example cannot tolerate alcohol and cannot metabolize it properly. That is a B1 mutation.