Thanks for flagging this work. We hadn't seen it yet. We did a quick pubmed search and pdgene search and don’t see any obvious links between ANXA1 and PD…‘annexins’ as a general class of molecule seem to pop up occasionally in PD papers around general inflammation mechanisms (mostly because some of these molecules act as markers of immune cells) but not as a BBB specific cause of PD. On the one hand, one could imagine targeting this molecule to open up the BBB for drug delivery but the safety aspects would be huge given it could obviously lead to neuroinflamamtion. So, while relevance for MS is interesting, not so clear for PD.

Debi