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Old 03-11-2013, 09:13 AM
soccertese soccertese is offline
Magnate
 
Join Date: Nov 2007
Posts: 2,531
15 yr Member
soccertese soccertese is offline
Magnate
 
Join Date: Nov 2007
Posts: 2,531
15 yr Member
Default xenoport working on improving intestinal absorption

not sure how vigorously they are pursuing this after clinical trial results weren't great.

http://www.xenoport.com/research_dev...technology.htm

http://investor.xenoport.com/release...leaseid=708154

Ronald W. Barrett, Ph.D., chief executive officer of XenoPort, stated, “While we observed an impressive reduction from baseline in ‘off time’ for 279/CD dosed three times per day, we are disappointed that this trial did not provide a clear indication of the benefit, other than dosing frequency, of 279/CD for advanced Parkinson’s disease patients compared to optimized doses of Sinemet. This may have been due to the large reduction from baseline in ‘off time’ observed once patients had their Sinemet dose optimized within the trial. Given that the goal of the trial was to demonstrate a clinical benefit over Sinemet, it was important that both treatments were equivalently optimized using specific guidelines. We intend to further analyze these data, including investigation of possible explanations for the outliers. We also plan to discuss these results with Parkinson’s disease experts and possibly with regulatory authorities to determine next steps, if any. We will defer further investment in this program pending the outcome of our data analysis and these discussions.”
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