Finz,

I just wanted to chime in that when I tried the switch from Kadian, now available as generic MSER, to a comparable (ie reduced mg) of Oxy ER, I absolutely felt more intoxicated, which I hated. Perhaps that would have gone away had I stuck with it, but I was satisfied enough with the (then) Kadian, that I discontinued the test after just a few days. I was unable to drive at all when taking the Oxy. But, this is again an example of how we all react differently to different meds. Those little tweaks of chemistry can be a big deal.