Which I had mine early on in my disease. This conclusion, earlier is better, can be supported by my experiences. Some early onset patients are extremely sensitive to sinemet. The slightest change in dosage can set them off. To much and they may fall on the floor and experience severe dyskinsias, to the point where they may be placed on a drug holiday. A drug holiday is when they withhold all drugs and start adding a little drugs each day until the patient responds. The patient is put into a medical forced coma state untill they can be taken out of the coma with a responsive state.

The advantage for these patients is to lower their need of Sinemet. My dosage of Sinement, after DBS surgery, was cut down by 2/3rd's prior to DBS. I am in very good shape for the condition I'm in.

Dianna