Sensitivities come with ANY drug...Plaquenil included. Even Lisinopril has about the same reported % of neuropathy side-effect as Plaquenil. And Lyrica has more then double the reported % of paresthesia...so it could be your lyrica.

I'm convinced that everyone responds differently, and anything is possible with any medicine. Other medicines or supplements must be taken into account as combos open doors to reactions that may have otherwise not occurred.

The fact that you had neuropathy symptoms before starting the Plaquenil clouds the issue whether it's responsible for the progression...since other meds you take also have the same small potential to cause it. Stopping is always an option to consider and my main point was to make sure you were aware of the half life and that is could take months to see changes (if it was the cause). Of course, it could just be the disease process and not medicine. Hard to tell for sure either way without a few trials. It IS imperative to discuss your vision changes with your ophthalmologist. Although your changes are not typical of how Plaquenil presents in regards to toxicity in the eyes, ANY change needs to be addressed immediately.

**Any changes to or trials with medicines need to be done one at a time...or you won't know which was the culprit and/or helpful.