Keep in mind this about percentages reported...

Those are % of those who reported a problem. Not % of all taking the drug.

It has been estimated that very few doctors report to MedWatch at the FDA... less than 5% or so. So the vast majority of serious reactions don't ever make this list. With a drug like Plaquenil, which is not commonly used, the study pool becomes very small. Doctors know that Plaquenil is potentially toxic, so they don't report. They assume everyone knows this already.
(most Plaquenil Rxs are generic today)

The Lyrica pool however is much larger because Lyrica is used more. More patients means more likely reporting too.
Lyrica however is still on patent, and very popular now. When doctors are told how wonderful it is by salespeople, and then they run into a serious side effect...they are more likely to report it, because it is a "surprise" or not well known.

That is just my take.
Many of the anti-rejection drugs like Prograf also show low
response on DrugCite.

There are patient sites online:
http://www.askapatient.com/viewratin...name=PLAQUENIL
and
http://patientsville.com/drugsatoz.htm#A
(but Plaquenil does not appear on this site at all)