Thanks for posting this....I seem to remember the same doggone thing happened in Alz. research with the protein they were targeting there....reduce that protein's plaques/tangles/whatever you want to call them....and people got worse. And fast.

I have always wondered if maybe the a-syn was formed as a protective mechanism...but never read anything to support this. Complicating things is the fact that they have found lewy bodies (the name for the clumps of a-syn, if I'm not mistaken) in people who never had symptoms of PD and they have not found them in people were diagnosed and being treated for PD.