Thread: New Therapies Targeting Alpha-synuclein may Cause Harm
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Old 03-23-2013, 04:59 PM
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indigogo indigogo is offline
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Join Date: Aug 2006
Location: "all the way over on the West Coast"
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Originally Posted by lurkingforacure View Post
Thanks for posting this....I seem to remember the same doggone thing happened in Alz. research with the protein they were targeting there....reduce that protein's plaques/tangles/whatever you want to call them....and people got worse. And fast.

I have always wondered if maybe the a-syn was formed as a protective mechanism...but never read anything to support this. Complicating things is the fact that they have found lewy bodies (the name for the clumps of a-syn, if I'm not mistaken) in people who never had symptoms of PD and they have not found them in people were diagnosed and being treated for PD.
The presence of lewy bodies in the brain upon autopsy has long been the only way to actually confirm a Parkinson's diagnosis. More recently, and supporting "Braak's staging", autopsies have shown lewy bodies more widely distributed, including in the gut.

From what I have read and been told, a-syn is a key to PD, but it is still unknown whether it's presence is protective or damaging.
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