Lisnopril? Do you know that this family of drugs can cause drug induced lupus? (ANA testing does not reveal this). I just got over a TERRIBLE reaction to this drug. My BP was sky high because of it! (caused a huge stress reaction which made my BP higher than ever). I was on 3 drugs to control BP and now I am on only one small dose of beta blocker! The ACE inhibitors cause an increase in a biogenic amine called bradykinin. This causes swelling, and pain, and redness of the affected areas. I had been on that drug for 10 yrs before this critical attack!

I strongly suggest anyone who is having major swings in BP and also taking an ACE inhibitor like lisinopril (or vasotec, altace, etc) to ask your doctor for a switch to another type of drug.
You might be shocked to see the changes!
Lisinopril is also not metabolized by the liver and is excreted in the urine whole. It inflamed my bladder and caused the most horrible pain imaginable. Once it was discontinued, this pain went away. It could be misdiagnosed as a bladder infection.

If a bradykinin reaction is severe enough it will affect your breathing and can lead to angioedema of the larynx and an emergency. Antihistamines and steroids do not change this and it is not a true "allergic" reaction.

http://www.uptodate.com/contents/ace...ced-angioedema

http://www.americannursetoday.com/article.aspx?id=7692

Some of the symptoms of RSD are similar to angioedema. So if you are on an ACE inhibitor, I strongly suggest you discuss a drug change with your doctor, to see if some of your symptoms resolve. Don't let this sneak up on you...like it did for me!

And if you have HAE and don't know it...you are in serious trouble. I am going to have this evaluation done, as soon as I am fully recovered from this lisinopril reaction! My doctor suspects I have HAE based on my medical history.

http://www.haea.org/

Lisinopril therefore can have a double whammy... drug induced lupus + angioedema attacks!

http://www.ncbi.nlm.nih.gov/pubmed/18797894