I too have been on predisone about 3 years - I am curently at 10 every other day. When I drop below that, adrenal fatigue kicks in. Those of you who are on low dose predisone and then drop to zero may be having that problem instead of an exaserbation (sp?) of mg. General overall weakness, overall "just don't feel good" and joint pain are my main problems with adrenal fatigue.

I think the way it works is that the predisone is doing the work for your adrenal gland and it just stops working. By reducing the predisone slowly, we are trying to give the adrenal time to start working again. But, sometimes, it just doesn't. As my endocronologist explained to me, your adrenal gland produces about 5 mg of the same hormone as predisone and you may be okay at an avg of 5 mg/day of predisone if your adrenal gland doesn't kick back in again - and that has been known to happen. Of course, it all depends on your body and how it is handling the prednisone - We are all different!