Now in this link right here:

http://www.dailymail.co.uk/health/ar...ink-brain.html

It says that when the GATA1 genes were turned on, the rodents acted depressed. In other words, depressive symptoms were instantaneous once those genes were turned on.

Now during chronic depression, there are constant episodes that go on all day everyday where cortisol rushes to the hippocampus and the prefrontal cortex, over-exciting those neurons and eventually killing them (if these episodes were to continue) causing shrinkage in those brain regions. And that shrinkage will then cause more depression.

Now for someone who is chronically depressed, can this person feel even more depressed just from one single or few of these episodes in which cortisol over-excites those neurons, or does it take time for the brain to eventually, over a long period of time, shrink from very many of these episodes in order for this person to feel even more depressed? In other words, does just one or few of these episodes result in instantaneous depression (like how there was instantaneous depression with the rodents when those genes were turned on)? Or, again, is it not instantaneous and takes time for the brain to shrink in order for more depression to occur in regards to the cortisol over-exciting those neurons? Again, I am just asking this question only in regards to cortisol over-exciting the neurons--not the genes or anything else regarding depression.