Quote:
Originally Posted by mg neck prob
[Hi Matt,
Remember we talked about neurogenesis occurs all thru life esp in the region of the hippocampus. Keeping that in mind our bodies are wired in away under stress to launch counter calming hormones so the hippocmpus doesnt get to hammered with cortisol. Sure there are moments under extreme stress rats may not find there way out of a maze --but once stress is reduced doesnt mean the damage is perm. To get to your point its something that occurs over time .
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I have 3 questions:
1.) So you're saying that for someone who is depressed, that there are no such moments where the glucocorticoids cause more depression instantly only in regards to them over-exciting the neurons and that, it's again, something that has to happen over time?
2.) Now if you add in the reduction of BDNF due to the glucocorticoids themselves (not due to the GATA1 genes or anything else) into my 1st question above, is it still something that has to happen over time and that more depression does not result instantly just from the glucocorticoids themselves over-exciting the neurons combined with reducing BDNF?
3.) So why is it that there are moments where someone who is depressed can have episodes where he/she feels more depressed instantly? It's again, not because the glucocorticoids themselves are over-exciting the neurons to death and reducing BDNF, is it? Is it because the GATA1 genes themselves instantly shut down BDNF and other genes responsible for neuron and synapse growth, causing this depressed person to feel even more depressed instantly?