I have two main side effects from Rebif...fever and/or chills within about 4-6 hours after I take my shot, and just a general body ache/hungove feeling the next morning. To combat the first, I take my shot at night before I got to bed and take a single advil gel tablet with it. That seems to be enough to put the fever/chills mostly on hold and let me sleep through it. If I forget to take the advil, I can count on waking up around 2-3am with either uncontrollable chills (the kind that even 3 blankets over me doesn't get rid of), or a full body flush heat that has me with all the covers thrown off and still feels like a full body severe sunburn.

For the body ache/hungover feeling, I take my shots on nights after I have worked out at the gym (tuesday and thursday) when I would wake up a little sore anyway, and sunday night, when I know Monday morning is going to suck anyway. It doesn't really change how I feel...just makes me have other things to attribute it to, so I don't tend to focus on it. I also use a bit of benedryl gel on the area around where I take my shot to sooth any itchiness that I might have felt. Not sure if it is really needed, but it is kind of a carryover habit from when I was on Copaxone.