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In Remembrance
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Join Date: Aug 2006
Location: Village of Selling, in County of Kent, UK.
Posts: 693
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In Remembrance
Join Date: Aug 2006
Location: Village of Selling, in County of Kent, UK.
Posts: 693
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Hi Madeitup,/Soccertese,
Levodopa decomposes in the body before it gets to the brain, by what is called a decarboxylation reaction, (loss of carbon dioxide) forming dopamine.
Carbidopa is added to the tablets to stop this side reaction. If you use a 50mg Sinemet tablet it is labelled 62.5 which means 50mg levodopa and 12.5 of carbidopa.
I have been able to reduce my sinemet to around 75 to 150 mg of levodopa
as I have become extremely sensitive to levodopa. At this level, I still suffer terrible dyskinesias with a half 50mg tablet, ie 25mg levodopa. Strangely
eating seems to trigger the start of dyskinesia
I am sorry I don't have a solution to the dyskinesia problem, I only wish I had.
Ron
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Diagnosed Nov 1991.
Born 1936
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