Now actually go ahead and forget those 3 questions in my previous post (don't answer them). Just answer this one question.

1.) For someone who is depressed, can there be temporary periods of more depression that can result only just from one or few instances where the glucocorticoids over-excite the neurons, or is it like you said, that more depression can only result from this over time (if these instances continue constantly over the course of a long period of time)? Again, this question is only in regards to the glucocorticoids over-exciting the neurons, nothing else that contributes to depression.