Science can't even indicate if there can be brief moments (or even longer or prolonged periods) where the loss of gained activity in the failing hypothalamus during chronic depression can be greater or less than the loss of pleasure activity only due to the glucocorticoids overworking those pleasure neurons? Again, as before, just a simple answer like "yes, science can answer this," or "no, science can't answer this." Again, this question is in regards to the hypothalamus overworking and failing (losing activity and losing activity that it gains) as a result during chronic depression.