Hi all- I've had MG since 2000. Had a thymectomy,went into crisis 6 mos later. Since then, have been on Mestinon and Imuran . During crisis, was put on a very high dose of prednisone which didn't help..finally 6 rounds of plasma exchange did the trick. I've had some ups and downs since then which have been handled by rest and increased dose of Mestinon. For the past 5 weeks or so, have been feeling worse than usual- first palate weakness, then arm weakness, back to palate weakness, now arm and leg weakness. I stopped working in 2001, and do try to take it easy and listen to my body. Aside from rest, rest , rest..is there anything else to really do? the increased Mestinon helps slightly. It's so strange- you start to feel almost normal and think that this setback is coming to an end..then its back, worse than before. Very frustrating..can hardly walk my dogs, or even get together w friends since my palate gets weak from talking. How do you guys handle it? Thanks for 'listening'!