I do have a question. I'm on 500 mg od Diamox twice a day. The side effects are awful. I can deal with the tingling and the change of taste but i'm concerned about the grogginess and loss of energy. I feel lethargic, especially the first few hours after I take it. I drive 30 miles to work and it's scary sometimes. At night it causes me to wake up every few hours and most morning I wake up with a headache that almost feels like a hang over. Does anyone know if your body adjusts to it? I've been on this now for about 3 weeks and where the PTC symptoms are better the side effects of the Diamox aren't. Any thoughts?