2 more questions (please answer each one):

1.) If it does lose activity, then there will be moments where some of the activity that it gains during chronic major depression is lost (resulting in little gain) and I'm wondering if there are moments where that little gain can be greater or less than the loss of pleasure activity during depression. Or can science not answer this question either. Again, just a "yes, science can answer this question," or "no, science can't answer this question" is fine.

2.) Now for someone who has chronic major depression, can there be brief moments where he/she will feel temporarily worse (more depressed) only just from one or few instances where the glucocorticoids overwork the neurons? Again, this question is only in regards to the glucocorticoids overworking the neurons, nothing else that contributes to depression.

Edit: I think I already asked this question before, but go ahead and answer it anyway with a yes or a no.