In regards to my 1st question in my above post that you just answered, are you absolutely sure that there is no scientific knowledge, methods, or technology, etc. that can answer whether that little gain (gain that is lost in the failing hypothalamus during chronic major depression resulting in that little gain that I mentioned in my 1st question above) if there are brief moments (like a second or more or less) or even longer moments where that little gain is greater or less than the loss of pleasure activity only due to the glucocorticods overworking the neurons? Again, you can just reply with "yes, there is scientific knowledge, methods, and technology, etc. that can answer this," or "no, there is no scientific knowledge, methods, and technology, etc. that can answer this."