Mokey,

I recommend you stay away from the Cymbalta samples until you have a doctor who is in support of you taking it. It will take a few weeks to see a difference anyway.

If you are going to self medicate, try a capsule of L-Tryptophan twice a day. It will show a change that day.

Have you ever had your B-12, D3, and folate tested ? You might be one of those who does not process (methylate, I think) B-12 and folic acid properly.

mrsD has quite a write-up in the Vitamins sticky.