Also, when you said “but I will tell you strictly my thoughts--not science--just based on my reading . If your asking me if a chronic depression person like yourself is on anti-dep meds and starts to feel better with depression symptoms. But that person cortisol levels are still high will there still be a greater loss of pleasure activity due to the stress hormones being high --my educated guess is YES.”

Now was that educated guess just based on a different subject, or was it regarding my questions of whether there are moments where the loss of pleasure activity can be greater than the combined activity gained by those failing and mildly failing brain regions during depression? Again, just a simple “yes, that educated guess was in regards to the loss of pleasure activity vs the amount of combined activity gained,” or “no, this educated guess was in regards to a different subject.”