I know that this is the same question as before and I keep asking it (it's the same question with a bit of difference every time), but I am obsessed over it and just need to make sure of your answer.

If for someone who has chronic major depression and the regulation of the glucocorticoids has completely failed, resulting in a vast number of pleasure neurons being overworked and overworked to death, can there be moments (brief, like a second or less or more or even for longer periods) where the rate of loss of pleasure activity only due to the glucocorticoids overworking and overworking a vast number of those pleasure neurons to death is greater than the rate of activity gained by the hypothalamus (rate of activity gained only in regards to the hypothalamus reducing (regulating) the glucocorticoids [which in this case has failed] combined with the rate of activity gained of the hypothalamus controlling depressive thoughts), or also can the rate of loss of pleasure activity only due to the glucocorticoids overworking and overworking a vast number of those pleasure neurons to death be greater than just one of those rates of activities mentioned gained in the hypothalamus during chronic major depression (again, either the one rate of activity gained in the hypothalamus that regulates the glucocorticoids or the other rate of activity gained in the hypothalamus which controls depressive thoughts)?

This question also applies to if the hypothalamus is failing during chronic major depression (where both of those gained rates of activities I just explained is lost, resulting in little gained activity), can the rate of loss of pleasure activity only due to the glucocorticoids overworking and overworking a vast number of those pleasure neurons to death be greater than either one of those gained rates of activities in the failing hypothalamus, or can it be greater than both of them combined? This question is also in regards to if the hypothalamus is mildly failing (where not as much of those both activities is lost) and also if the hypothalamus is not failing. This question is also in regards to if this person has intense episodes of major depression and also if he/she goes from mildly depressed to intense episodes of major depression, and is also in regards to when this person only experiences mild depression, and also in regards to when this person is experiencing prolonged periods of these forms of depression (both major and mild), and finally in regards to moments when this person experiences hardly any depression at all.

Again, just a simple answer "yes, I can take a guess at this," or "no, I can't even begin to guess at this." I know that you might say "no, I can't even begin to guess at this," it's just that I have an obsession with trying to absolutely make sure in regards to your answer to this question. Again, just choose one of those answers in quotes--you don't have to explain anything, but you can if you want.