Desiccated thyroid is the only thing that helped me (with Hashimoto's). The synthetics have only T-4*, and my body wasn't converting any to T-3. The desiccated has both and made a huge difference.

Just thought I'd throw that out here.

*There are synthetic T-3s, like Cytomel, but the usual Synthroid, Levothroid, etc. are only T-4.