Originally Posted by mrsD

Most of us with neuro symptoms keep our level above 1000.
Some more than others.

Going really high is not necessary unless some people have the rare transcobalamin problem. When this is low, transport of B12 is less efficient and it is thought then to keep the blood level higher, to make up for that loss. But the days are early for transcobalamin decisions, so I can't say with certainty yet, since everyone IS different genetically. Tests for transcobalamin are just beginning to be offered.