Originally Posted by mrsD

250mg B6 twice a day? Not a common treatment in the US anymore. For a short burst may be helpful, but over time you may see side effects from this. 500mg a day of B6 has been implicated in long term use to cause neuropathies(toxicity) in some people.

I'd continue with your methylB12 and be sure to take on an empty stomach.

The antibodies you mention attack the cells that make intrinsic factor. Intrinsic factor binds to B12 in food and helps with its absorption. Acid is required to release the B12 from animal proteins, first. Autoimmune disease is sometimes a sign of gluten intolerance. So it might be a good idea to be tested for that as well.

Did your doctor mention low acid in your stomach as well?