BP: I tend to agree with you on Sinemet side efffects & also that some doctors & even some patients don't want to hear my experience if it doesn't jibe with theirs. Sometimes people generalize and assume all Parkies are alike in symptoms & treatment responses, but it just ain't so. Sinemet doesn't do much if anything for my main symptom, a really bad tremor, but at this stage, 6 years after diagnosis, it does seem to help improve slowness, sleep, and at least one specific horrendous upper back pain. Unfortunately, it also gave me some bad side effects: weak legs and right foot/toes & leg curling upward & inward plus muscle cramping. I keep the dosage low, but seems nothing's ever perfect in Parkie land!