I have had IVIG for 3 years every 2 weeks. I am at the infusion center for 6 hours in a private room. I need to bring my own lunch and snacks. I premedicate with benadryl and tylenol. I get tired from the benadryl and usually sleep for about 2 hours but it prevents reactions to the IG. We experimented with various rates until we found the one that I did not get headaches with - a little slower which takes longer but it's worth it. Drink lots of water before , during and after and you will avoid headaches. I am very tired when I get done and usually sleep as soon as I get home most of the night. In the beginning I used to be exhausted the following day but that has gone away. I can't tell you the difference it has made in the way that I feel. Best of luck to you - IVIG is a wonderful treatment.