The studies done with B12 orally showing various absorption rates, were done on an EMPTY stomach.

One thing you will see as you investigate various supplements, is that the makers of them are imperfect. And Big Pharma who makes drugs, are also imperfect.

Do what you think is best. If you want the BEST results take your B12 on an empty stomach.

Metanx was NOT enteric coated either... and P5P is best protected from stomach acid with an enteric coating. The better manufacturers of it provide it this way.

Taking vitamins with food is a generalization. It reflects the need for acid in the stomach for many of them. But taking microgram doses of B12 (and this pertains to some RX drugs also), with food, loses the drug in the fiber of the food, and it won't get to the lining of the intestines adequately. So in the case of B12 you need an empty stomach with nothing in the small intestine, to absorb the tiny micrograms of the cobalamin.

You are not going to absorb 1000mcg of methylB12...per dose. If you are lucky and do it correctly, you may absorb 13 micrograms of that huge dose. (this was found in the study I provide on the B12 thread. 13mcg a day is about 3 times the RDA and over time is adequate to improve B12 status in most people).

So I suggest you do it the way that has been opened for you and disregard the makers of Metanx, who are in error on this factoid.