Quote:
Originally Posted by soccertese
i've read about frequent dosing using "liquid" sinemet in a number of general books on pd, one being "THE PARKINSON'S DISEASE TREATMENT BOOK" and a general procedure on calculating sinemet dosage. in all cases, they just recommend storing the mixture in a bottle with measurements marked on the side and pouring out the correct amount or having a cup with the correct volume marked on it. i imagine it is a hassle having to mix the stuff up daily and if you make a mistake can be problematic. not sure if you need to refrigerate it. seems L/C dissolves so readily and is easy enough to split you can take small amounts without having to dissolve it.
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What would this have to offer over an extended release formulation? Isn't the effect the same, you're getting a constant feed of the drug instead of large amounts?
Or does the CR not keep the blood concentration high enough and mini bolus administrations are preferred?